Director - Dave Green
- Leonardo - Pete Ploszek
- Michelangelo - Noel Fisher
- Donatello - Jeremy Howard
- Raphael - Alan Ritchson
- Splinter - Tony Shalhoub
- April O'Neil - Megan Fox
- Casey Jones - Stephen Amell
- Vernon Fenwick - Will Arnett
- Rebecca Vincent - Laura Linney
- Shredder - Brian Tee
- Karai - Brittany Ishibashi
- Baxter Stockman - Tyler Perry
- KRANG - Brad Garrett
- Bebop - Gary Anthony Williams
- Rocksteady - Sheamus
- Knicks Cancer - Carmelo Anthony