Fable III - Final fight family vanishing glitch.
All that time invested in the game wasted, never touched or will again anything Fable, Lionhead or Peter Molyneux.
I had the collectors edition as I had loved the first and second games, there was a fair amount of DLC included that was to come later, once I found out about the family vanishing glitch it was too late as I only discovered it was an issue when it had happened to me, I remember that they were working on a fix but that it would take time, but once the family had vanished there was no way to get them back and the entire game had to be played again, I was incandescent with rage, I even wrote a letter to Lionhead/Peter Molyneux with a copy of my receipt asking for a refund for releasing a game that contained a completely game destroying glitch/bug, but I never received a reply from them, I felt robbed of my money and more importantly time and effort I had invested in the game.