It's way more comfortable with a higher refresh rate and native display port connection rather than streaming video over USB which can have issues, especially if you want longer cables. However it also uses a single LCD screen rather than twin OLED and so has only software IPD.
It's only 8 hz less but the Oculus Rift S is 80 hz which is already 10 hz less than what was considered the minimum desirable for the feel of presence in VR and what was basically the standard before it (and before Index higher rates), 90hz, so that makes the Quest a noticable 18 hz less.
According to Linus a very slight but perfectly playable lag is apparent, not with the VR view looking around but the hand tracking, even when you use Link (never mind the wireless connection some people play with) vs natively playing the game on Quest (if it has a port) or in a native PC VR set.
I time stamped where he first tries Link and says it feels jello-y compared to native PC VR, then he tests wireless, more Link at
9:16 as he touches on the slight lag again. At
9:53 he plays a game natively on Quest and says it's lagless so it wasn't the controllers or anything other than Link.
It's worth watching the whole thing maybe as there's also a part where as he moves too fast he catches a glimpse of blank black space as the video stream only covers a given safe area but it mostly happened wireless, he had to basically try to confirm it can happen when using Link too.
He still likes it and is positive about Link overall though if you watch past that last time stamp, I was just being thorough with the differences as far as I've known them to be, I didn't wanna mislead anyone if you got it and then noticed the slight lag yourself and said oh no he tricked me