Well I already ran into 3 issues at the beginning of the game.
-The part where you are chasing Sundowner, I managed to slip past him and he somehow got stuck behind me and was running in place with half of his body in the ground texture.
-During the 2nd part of the Ray fight (on the rooftop), after jumping from missile to missile and then chopping off it's arm, it grabs Raiden with it's mouth and throws him into a clock tower. Well that clock tower didn't appear and Raiden was stuck in the pose at the moment he hits the wall (which was invisible). This caused a soft lock. The next scripted sequence didn't continue, but the music did, and I was able to access the start menu.
-Upon restarting the game, it got stuck in a infinite load screen...
Not feeling too great about this so far. Only 10 minutes in and I already came across 3 really annoying issues.