Just my tuppence worth for this thread:
I've never really had any issue with any of these "progressive politics", as they've been called. I'd go so far as to say I'm apathetic.
I'm 38 years old and I've seen the world change a lot as I've grown up. I've seen racism decline (and then in some circumstances resurge, but that's another topic entirely), I've seen seen Alan Turning receive an official pardon for being "homosexual" (how dare he in the 1940s), I've seen homosexuality, and indeed a range of 'sexualities' become accepted. Mixed race marriages become commonplace, same-sex marriages become the same.
I've watched as unhappy people have finally been able to be themselves without the wailing and gnashing of teeth that used to go with it. I've seen uplifting stories of communal acceptance where in the past there'd be suspicion and hatred.
The world has changed as I've looked on, and for the better.
There will always be a pushback to change, and a lot will be met with intolerance, hatred and fear. I understand this completely. Alien concepts to some are scary and I'd never chide nor talk down to someone for expressing that.
However, I think people need to step back, forget about agendas, forget about labels, and think about the world as it is now. Using TLOU2 as an example, I understand folk thinking that "homosexuality" may be being pushed down our throats, that we're being made to accept this, that they're using this game as a carrier to further agendas.
Personally, I don't care. Not even that. As said, I'm apathetic. This is the world now. People you see on the street will be gay/straight/other. People you see on the street will be white, black, hispanic, asian etc. These people will be in love with someone else, and that relationship may not tally with your idea of "normal", but that's how it is in the world now. It's normal, and people are happier for it.
So when such things pop up in a game, why is it an issue? I may be naive, but to me you may as well complain that a game is taking place at 6 in the morning before you've had your coffee. You may not agree with it, but it exists and life moves on without it impacting you a jot.
Again, using TLOU2 as an example - I understand that folk may be actually having issues with the "love story" aspect of the game. I can understand that also, but that's not an agenda issue. That's a narrative issue. Personally I don't want to play a love story (not that I think it will be), but certainly the identities of the couple involved shouldn't - nay doesn't - matter.
In short, as this has been a bit of a stream of consciousness post, I think people see agendas, SJW-ing, Alt-Righting etc. because they're so accustomed to having to rail against change. People who have issues with things been pushed on them rarely have issues with the "agenda", it's usually an underlying issue OR they simply feel the need to rally against something they see as different for the sake of it.
There's nothing here to be scared of. It's a story set in a time when we're more human and more accepting of ourselves. Or, should I say, a story written in a time when we're more human and more accepting of ourselves. Enjoy the story as you would enjoy a walk in the park - watch the world go by, empathise where you would, disagree when you would. There are no agendas, there's just life.
tl;dr: Meh.