Sequelitis wasn't a fluke. Ego said it himself in the video: "Jump and shoot man". His philosophy about game design only works if the game mechanics are basic. Mario, Sonic The Hedgehog (original), Mega Man... all of these titles were simple enough for the designers to just say "Let the players figure it out". Gameplay systems, despite what people want to remember, were much simpler 20 years ago for obvious reasons (technical limitations, stuff like this).
Fast Forward to current day. An Action Adventure game can have RPG elements (experience, leveling, stats) mixed with a crafting system along with a combo system and any number of other mechanics. WRPGs are touting skill trees, leveling systems, stats, crafting systems, in game economies, shops, towns, cities, equipment systems, classes, ranks, etc. JRPGs are doing their best to expand outside of their Turn Based roots (Resonance of Fate, Final Fantasy XIII, etc). Ego's simplistic approach to game design does not work when faced with complex game mechanics. And Game Grumps showed this in spades. Any time Ego was faced with a chance to prove "gamers are smart enough to figure this out on their own", he failed. He takes half the video to figure out stuff and then blames the game design anyway.
The chaotic and improv nature of Game Grumps just allows Ego's close minded and stubborn philosophy to come to the spot light.