ML in this years version has had a complete overhaul. You still start in division 2 but it's now 18 teams and not 12 or whatever the previous ones were. Then, there are 5 'major' leagues running at the same time - England, France, Spain, Holland and Italy. If, like me, you like to have leagues of random teams then you can do that instead of it being like in real life.
There is much more focus on the day-to-day running of your team. You have a coach, scout, youth team manager etc all of which can be upgraded. You can 'train' players in your team by allocating them specific skill points to certain areas. You also have a youth team where you can sign any promising players.
Champions League and Europa League are now integrated into the ML which gives it a much more realistic feel.
Whilst I've loved the ML in every version of Pro Evo, I agree that it was becoming very repetitive each year. This year however, is a vast improvement. If you enjoyed the ML before then you will absolutely love it now