The previous film, Resident Evil: Retribution ended with Alice having her superpowers restored and allying with former enemy and video game villain Albert Wesker (Shawn Roberts). Wesker needing Alice's aid to combat The Red Queen, an Umbrella Artificial Intelligence and primary antagonist from the first movie, who now wants to eliminate humanity for some reason.
As is now standard for the series, the set up from the previous movie is tossed out immediately as Alice awakes in a devastated White House having been betrayed by Wesker. Approached by the Red Queen, she's informed that she only has 48 hours to save the 4,472 people left alive on the planet, that number not including the numerous Umbrella employees Alice will dispatch along her way.
...
What follows is a mess of unclear action, scenery chewing, unmemorable characters and maddening plotting as Alice heads back to Raccoon City and The Hive from the first film, in search of a cure for the T-virus and an end to Umbrella once and for all.
The biggest criticism to that can be leveled at Resident Evil The Final Chapter is one that Umbrella executives might very well level at Alice herself; one of wasted potential. As the final chapter (it isn't really, more on this later) Anderson had the opportunity to take characters and monsters from the various films and games and remix them into a greatest hits package for fans. Instead, he decided to tell a very generic, post-apocalyptic tale. Some of the iconic Zombie dogs turn up at one point, but they don't do much and the sequence is not a patch on the Alice vs. zombie dogs sequence from the first film from fifteen years ago.
...
The whole film seems like a step backwards with nothing coming even partially close to the pacing, tension, action and most importantly clarity of that scene or any of the other fun standouts from the series.
Something resembling a Licker appears later in the film but the camera is so close to the action and edited so quickly, that it's impossible to make out the creature in any detail, and the action becomes hard to follow.