I'm all for them using different villains this time around. It's too early to play with the symbiotes IMHO.
I mean almost every game in the last few years had them in some form?
Ultimate Spider-Man, Spider-Man 3, Web of Shadows, the 2 level based brawlers from Beenox, Amazing Spider-Man 2 and I'm sure I am missing a few games.
Just let it go, introduce Venom/Carnage as the big bad in one of the sequels. Give me villains like Mr. Negative, Kingpin... Mysterio... maybe Dr. Octopus? Symbiotes are way overdone and I'm tired of having games that focus on them just cause Venom had a few cool storylines back in the day. I'd prefer more grounded villains this time around.