*SPOILER BREAKDOWN*
I really do think they're trying to throw every possible angle of what could be happening in the game at the player to confuse what is actually going on. We have the possibility of crazy scientific experiments, the possibility of satanic rituals and cults, the possibility that our main character is insane, and so many other possibilities.
This trailer showed a bit more of the Satanic angle of the game, showing things like a goat sacrifice and a cult logo. There's even a scene after Sebastian crashes the ambulance where he walks off from the hill, and see's the church shining off in the distance with a huge beacon of light.
Previously we've seen monsters that look liked barbed-wired zombified Ganados, Boxman, and the lady with multiple arms. This trailer added a woman in a straight jacket with a mirror for a face, we see what looks like a cult member in a grey cloak wearing a plastic mask next to some mannequins (this looks condemned inspired, like he was posing as a mannequin), we see a giant enemy lunge at him from the door (but those who pay attention will notice the bottom half of a human dangling out from underneath the beast, implying it's a mutated human), and a monster in the water with translucent skin and a huge jaw and mouth.
We saw a scene which looks like Sebastein's glasses-wearing cop friend being put on a guillotine. Could be his death scene, maybe not. Maybe if we're going into psychological horror, even if he dies there that might not be the last we see of him. We also see a quick flash of the lady cop that comes with him in the sewers later in.
On the psychological side of things, a few dropper hints here. Firstly we see Sebastian walking towards a farmhouse in a field of sunflower fields. But later in the trailer we see a family portrait of a parents and two children, The son's face is ripped out be he sort of looks like Sebastian, and the sister's face is shadowed in a way that looks devious and evil. We also see Sebastian in an electric chair.
We see a scene of doctor cutting open a body for some reason. and there's a nod to Resident Evil 1 as he turns. Notable is that Sebastian is with another doctor at the time who looks onward at the crazy doctor with him. Later we see Sebastian at the body as opposed to the doctor and opening him up with a knife, but the body comes alive as he cuts it.
There's an odd scene of Boxman banging his boxhead with his hammer rapidly.
And then of course psychic cloak guy, we see him in the opening attacking Sebastian, and later on we see him again in a church levitating him somehow.