In all seriousness, they need another remote location that is not typical for video games. We've had Africa, tropical islands and the Himalayas so far - maybe something like an abandoned city in Eastern Europe, an Arctic wilderness or a South American jungle. Then they can have another Blood Dragon-style spin off focusing on something wonderfully dumb like dinosaurs or zombies. Personally I'd like to see the next Blood Dragon be a satire on ridiculous monster and/or alien b-movies of the 1950s.
EDIT - when I say jungle, I mean a properly dense and vast jungle, not the crap that we usually get in videogames. The 'jungles' in Far Cry and FC Instincts were rubbish.