I feel this wins because it's not only stood the test of time (I think it originates from 2004) and it's wide spread too, I know it's had popularity in the Asian forum scene.
There was one incredible .gif in the Banderas meme era with Stallone from the Rocky IV training montage spliced into the same .gif. Had me dying every time.
There's no way in hell that anybody else is going to remember this extremely short lived YouTube video fad. But I still laugh at the Other M "Remember Me?" guy from time to time.