First of all, the Wii controls have been pretty well implemented. While there aren't any new weapons, the emphasis has been placed on the guns rather than hand-to-hand combat. Aiming a gun works exactly as it did in Resident Evil 4, with the remote's trigger used to enter aiming and the A button for firing. The same chairs, baseball bats, and guitars can still be picked up for the personal touch, and you have two methods for attacking. The A button will swing whatever you have in your hands, but you can also shake the Wii Remote if you want a stronger attack. It basically depends on how lazy you feel like being at any given point.
If you manage to stun your opponents with a gunshot or a powerful strike, then you can follow up with a finishing move by waggling the Wii Remote. The same technique works for shaking off a zombie who's trying to take a bite out of you, or if you want to recover from an attack like Adam the Clown's gas balloon attacks. We particularly liked using the baseball bat in the Stun mode, as you can shake the remote to build up a superpowerful strike to send the dazed zombie flying through the air.
Capcom claims that the entire game will be pretty much exactly the same as the original in terms of story progression and endings. What has changed is that a number of annoying features have been ironed out following player feedback. The save system is now much more regular and occurs at the end of each case. You'll also be able to go away and rescue civilians without receiving a time penalty on the case you're working on. And you'll be able to hold on to more weapons, with up to four slots dedicated to firearms.