This is a great thread that always needs to exist on this forum in some capacity. I have been playing a game of pen and paper 2nd edition Shadowrun for a few months now and it's always awesome to get more inspiration for dialogue and character building elements. Gonna be adding a bunch of the recommendations here to my Steam sale cart that I am amassing right now.
Still on the fence about VA-11 HALL-A though. One of the primary reasons I like cyberpunk stuff is the aesthetic and this game's anime artstyle just doesn't quite do it for me (I feel like I have been saying that a lot recently. What happened to me and anime? I used to love it.)
EDIT: Read Only Memories was a pretty good point and click cyberpunk adventure, though it's much less dystopian than Blade Runner.