Wiethoff hasn't given up on Red Dead. He attends comic conferences every now and then. But don't expect to see him in another big-budget game anytime soon. "I'd be thrilled if it was something I wanted to do," he says, "but I have obligations now I didn't have before. It's different."
I never fully understood these types of posts. They always seem to pop up so that every quality posted gets deflected with "But I can get [insert mentioned feature] from this other game I'm already playing." If someone has to "sell" you on it, you probably were never interested in the first place.
They're guaranteed to do a "Red Dead Online" given the success of GTA Online but there's no way they don't do a full single player mode as well. I think the teaser is an indicator that it will have multiple protagonists like GTAV.
The Housers have said that they'll always do big single player games. I'm sure there will be a bigger focus on Red Dead Online this time around, but multiplayer only would go against the spirit of the R* brand.