Sure, but 10,000 sqft is gigantic and about what EA brings to show off 6-7+ games.
There would have to be at least 4-5 notable titles for this size to make sense. Umbrella Corps might be one and Monster Hunter another, but I'm expecting at least two product announcements from them by the time the show floor opens.
It's probably about time for Capcom Vancouver to show something and then maybe a game from Japan.
There's a very high chance for a few announcements. They listed DMC as a series they plan to release a game for in the next few years in their financial report and going forward notes, but maybe to soon for that. Dead Rising was also shown to have something coming out in the next few years, so maybe something new from Dead Rising world.
This year is the Resident Evil series 20th anniversary. We know that Resident Evil 7 has been in development for 3 and a half years now, so very high chance that'll be shown. There's also a semi-high chance we may get a teaser for REmake 2 (the original REmake only took 13 months of development, the RE:Reborn fangame team who got to see RE2 REmake in the Capcom offices said they were excited by what they saw and we may be seeing some of "Sooner than you might think," and as of right now REmake 2 has been in development for about 6 months, so probably have some sort of teaser). Plus whatever other stuff thety may have RE related.
SFV characters and content shown probably for going forward. Probably some other surprise announcements.
As of May 2, 2016, this is the list of exhibitors with primary assigned booth available via the ConnectME dashboard. There is nothing too interesting here, but two things of notice:
SEGA Europe has no longer got the booth 5010 listed. Now it just says TBD.
Many companies have TBD (to be determined) under booth
The interactive floor plans are still under a 302 redirection, so I can't access them at the moment for better info. But the information in the list tells that there's still a lot of work to do as many companies still haven't got assigned booths.
The E3 2015 floor plans in full were published on May 30, 2015.