You know, a game in a genre that you would have normally been interested in, if you didn't find the art style so off-putting.
One example that comes to mind immediately is Dust: An Elysian Tail.
I was interested in this after hearing it was an entirely hand-drawn 2D brawler, and it got high praise from Giant Bomb, too, but good God, that is some of the ugliest artwork I've ever seen in my life. I can't look at the characters in that game without wanting to throw up. It's like it came straight from a Deviantart page. I still haven't played the game, simply because I had such a negative reaction to its art. Yeah, it's shallow. Yes, it's irrational. Maybe there is a good game underneath the bad art. But I can't bring myself to play a game that makes me cringe just looking at it. Maybe someday, though.
Have you ever experienced this, GAF?
You can't be saying that Dust is ugly. You don't like furries? Good, I don't like them either. But don't say the artwork is "ugly" because it's exactly the opposite: beautiful and masterfully crafted.
And dude, the character design is not that bad. Again, I dislike furries, but Dust makes me forget that Deviant Art ever existed and takes me back to the old days when we had not cringeworthy animal heroes (Sonic, Star Fox)
I do remember that some female characters in Dust looked overly-humanized, and I never liked the design of the sidekick, but the overall experience was beautiful.
The main character is pretty badass, for furry standarts of course.
I think I understand what you are saying, OP, but "ugly" isn't really the word you are looking for here.
As for me, I can't play any modern Sonic game since Dreamcast because of the stupid redesign of the characters. Sanic was perfect as he was.
Also, Shinobi for 3DS had pretty ugly graphics and bad art direction, which eventually led me to give up on playing it despite of my love for the saga.