All I really listen to is Weekend Confirmed, 8-4 Play, and Game Scoop. As a former IGN reader from the early 2000s and then a big 1up fan for a few years there, these are the only guys I feel any sort of connection to. I tried a few others (Bombcast, Gamers with Jobs, Player 1) awhile ago, but it's hard for me to get into a new show with new people for whom I have no familiarity. Ive been meaning to try Bombcast again, as it (and I guess most things Giant Bomb) gets such praise on GAF.
Game Scoop is an enjoyable listen, but a lot of their views and opinions come across as sort of "frat boy dude bro". It often feels pretty lowbrow. Also most of my IGN favorites have long since moved on, and outside of Daemon, Greg (when he isn't being obnoxious), and Anthony (who isn't on the show nearly enough,mand when he is doesn't talk enough) I couldn't care less about the cast.
8-4 Play is great listen. The work they do outside of podcasting is interesting. They cover stuff that others miss, although it can be frustrating hearing about Japan's upcoming releases when I know that it won't come out here for some time. Mark is always great, and John too. JJ initially didn't do it for me, but he's grown on me. JJ and John's voices sound similar to me sometimes, and I can't tell who is saying what. Great podcast overall, and for me, tied with Weekend Confirmed.
Weekend Confirmed gets a huge boost for having Garnett and Jeff (if Jeff ends up moving as a result of TRS ending, I don't know what I'll do). Indie Jeff I really appreciate as well. I often disagree with at least one host's opinions, but that's not always a bad thing. Also as someone who is now married with children and short on gaming time, I enjoy hearing Garnett's tales of domesticated life. This podcast can come across as unknowledgable at times, but I still find the personalities enjoyable. The guests of the ever-rotating 4th chair are usually good, and this show gets some pretty good industry guests as well.