Yes. If you can, read Time Runs Out first to get some of the set up, but you can jump into Secret Wars cold and be fine.
Now, if you want to be crazy, read the entire runs of Avengers and New Avengers by Hickman for the multi year set up for Secret Wars.
Extra crazy? Read Hickman's Fantastic Four and FF run too.
is there a handy list for this stuff like that one for Marvel cosmic?