Hints that have already been given:
10:
-PC title
-Title sounds like an edu-game
-Actually a mix of adventure/action/puzzle, iirc.
50:
-Not related to Mario, DK, or Nintendo
-Spinoff title (not a part of the main series)
-Released for the PS1
New hints:
11:
-PS2 platformer
15:
-PS2 action/adventure (?) title released in 2004
16:
-SNES RPG
-Published by Enix in North America
18:
-Where's isamu when you need him?
29:
-Xbox title
39:
-Involves furred characters
-PC title
40:
-Only released in Japan
-Released in 2002 for PS2 and GC
44:
-PC title
-Sci-fi (?)