When it comes to fighting games, Capcom will be fine. Both versions of SF4 sold well enough and even Tatsunoko v. Capcom managed to sell past expectations and have relatively decent legs. MvC3 will sell based on hype alone.
But I'm pretty worried about their other efforts at this point. While I really don't want them to fall back into old habits (Re-hashing Resident Evil and Mega Man by the year), they're definitely setting themselves back to square one with these consecutive super bombas. Bionic Commando and Dark Void might have encountered problems due to their outsourcing strategy, but Lost Planet 2 was mostly a result of bad decisions by Capcom internally. I wonder how Capcom will handle things if Dead Rising 2 also bombs, especially since their big hitters (Mega Man, Resident Evil, Devil May Cry) are MIA at the moment.
They could bring back older, popular franchises and see how that goes (Onimusha and maybe Breath of Fire), but something at Capcom has definitely gone wrong in the past year or so.
Also, how much did Monster Hunter 3 sell anyway?