To be honest, I found it a little odd how quickly Virginia became William's associate. Time moves by much too quickly in the pilot - She's a lounge singer, then a secretary, and then finally she jumps all the way up to being his partner in the span of 60 minutes. I would have appreciated a more Don/Peggy Mad Men esque approach, spread out across the first 3-4 episodes, but I guess they felt the need to get things set up as quickly as possible so they could plow forward with the rest of the season. Still, this is premium cable and audiences are supposed to be more patient than that.
I also thought it was sort of odd that they set Virginia up from the get go as an expert of female (not just of her own, but apparently of all women's) sexuality. She seemed a bit omniscient, and, frankly, came off as something of a Mary Sue. I trust that they'll add some more dimension to her character as the series progresses, however, so I'm not worried.
Also, towards the end of the episode, Williams and Masters told Beau Bridges' Barton Scully that they had already debunked a bunch of myths regarding female sexuality, but they failed to tell him (and us) just what, exactly, they had debunked.
Ray Donovan just had a black screen with white text instead of an opening credits sequence and it looks like Masters of Sex is following suit. Disappointing. :/
I laughed when the prostitute said "Good for you!" after the guy orgasmed in the beginning of the episode. She was a fun character, and I hope they keep her around for a while.
Margo Martindale! I fear that this might be the first and only time she appears on the show, but I would love it if she popped back in every now and then.
I already can't stand Ethan Haas. Party because the character is written to be an abusive petulant child, but also because Heroes ruined Nicholas D'Agosto for me, I think. It doesn't help that he just doesn't seem to be a very good actor.